Name: Anti-P16INK4a antibody
Price: 337.00 USD

Overview
- As one of the cyclin‐dependent kinase inhibitors that inhibit cyclin‐dependent kinases (CDK) 4 and 6, p16INK4a is encoded by the tumor suppressor gene CDKN2A. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor‐derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa
  
  Reactivity
  
  human
  
  Clone
  
  MX007
  
  Immunogen
  
  Recombinant human p16INK4a protein (aa1‐ 156)
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Cyclin-Dependent Kinase Inhibitor 2a; Cyclin-Dependent Kinase 4 Inhibitor A; Cdk4i; Multiple Tumor Suppressor 1; Mts-1; P16-Ink4a; P16-Ink4; P16ink4a (Gene ID:1029; UniProt:P42771)
  
  * For research use only