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Overview
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BCL‐6 interacting corepressor (BCOR) is a 1, 755 amino acid protein that associates with histonedeacetylases to transcriptionally repress BCL‐6. BCOR mRNA is ubiquitously expressed in various tissues. However, the BCOR protein expression in adult tissue is limitedto testis only. Recently, the BCOR rearrangement was detected in a subset of small blue round, spindle cell, and undifferentiated sarcomas, which results in overexpression of BCOR protein in these tumors, including small round cell sarcoma (~100%), clear cell sarcoma of kidney (100%), high‐grade endometrial stromal sarcoma (100%) with YWHAE‐NUTM2translocation, and subset of synovial sarcoma (50%). The list of BCOR positive tumors is still expendi
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