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Overview
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Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule ofthe immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-celladherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 andnectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized atadherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpusvirus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor.Disruption of mouse nectin-2 leads to infertility of male mice. The antibody cross reacts with humannectin-2Immunogen: extracellular domain of mouse nectin-2
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