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Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed tosmoothelin are useful tools to monitor SMC differentiation. Smoothelin is exclusively expressed in fullydifferentiated (contractile) SMCs. RNA and protein analyses revealed a broad species distribution ofthis protein. Smoothelin has also been detected in smooth-muscle neoplasms. Cells with SMC-likecharacteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscledo not contain smoothelin. Confocal scanning laser microscopy of tissue sections and cells in cultureshow a filamentous organization of smoothelin colocalizing with actin stress fibers. In immunoblots twomolecular weight isoforms are detected i.e. a 59 kDa isoform specific for visceral SMC (smoothelin A), and an isoform with a molecular weight of approximately 100 kDa in vascular SMC (smoothelin B).Human smoothelin is encoded by a single copy gene which is loCated on chromosome 22.Immunogen: cytoskeletal extract of Chicken gizzard
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