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Overview
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Recognizes human Toll-like receptor 9. Toll-like receptors (TLRs) are highly conserved fromDrosophila to humans and share structural and functional similarities. TLRs constitute of a family ofpattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens(viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns. Activation of TLRs, a family of at least 11 different members that function either as homo-orheterodimers, leads to activation of NF kappa B-dependent and IFN regulatory factor-dependent signalingpathways. TLRs have a central role in innate immunity and are also required for the development of anadaptive immune response. TLRs are expressed by various cells of the immune system, such asmacrophages and dendritic cells. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens.Immunogen: Purified-fusion protein of extracellular domain of human TLR9 (AA 1-815) and humanIgGFc
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