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Overview
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Recognizes mouse nectin-3. Nectin-3 is a 83 kDa type I transmembrane glycoprotein.Nectin, originally isolated as poliovirus receptor-related protein (PRR), is a cell-cell adhesion molecule ofthe immunoglobulin supergene family. Nectins are calcium independent immunoglobulin-like cell-celladhesion molecules consisting of four members, nectin 1-4. Nectins homophilically and heterophilicallytrans-interact to form a variety of cell-cell junctions, including cadherin-based adherens junctions inepithelial cells and fibroblasts in culture, synaptic junctions in neurons, and Sertoli cell-spermatidjunctions in testis, in cooperation with, or independently of, cadherins. Both nectin-2 and nectin-3 areubiquitously expressed, whereas nectin-1 is abundantly expressed in brain. Nectin-2 and-3 areexpressed in cells where cadherin is not expressed, such as blood cells and spermatids. All membersof the nectin family have two or three splice variants.
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