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Overview
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Detects surface immunoglobulin on normal and neoplastic B-cells. Anti-lambda staining isseen in B-cell follicles of human lymphoid tissue. When dealing with B-cell neoplasms, thedetermination of light chain ratios remains helpful. Most B-cell lymphomas express either kappa orlambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positivecells. If only a single light chain type is detected, a lymphoproliferative disorder is very likely.
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Overview