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Overview
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Mammaglobin is breast-associated glycoprotein distantly related to secretoglobin family that includeshuman uteroglobin and lipophilin. Anti-mammaglobin labels cytoplasm of normal breast epithelial cellsas well as primary and metastatic breast carcinomas. Absence of mammaglobin expression is typicallyseen in prostate, kidney, colon, rectum, small intestine, stomach, pancreas, lung and thyroid tissue.2, 5Mammaglobin may be used as part of an immunohistochemical panel for determination of metastaticbreast carcinoma and tumor of unknown primary origin.
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