Name: Anti-Keratin, Pan antibody
Price: 331.00 USD

Overview
- Twenty human cytokeratins are resolved with two‐ dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50’, 48, 46, 45, and 40kDa. The basic keratins have molecular weights of 65‐67, 64, 59, 58, 56 and 52kDa. Members of acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with cell type, differentiation status and environment. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. MAb AE1 recognizes the 56.5, 50, 50’, 48, and 40kDa keratins of acidic subfamily, whereas the AE3 MAb reacts with the basic keratins of 65‐67, 64, 59, 58, 56, and 52kDa. AE1/AE3 reacts with keratinized (56.5/65‐67) and corneal (55/64) epidermis, stratified squamous epithelia of internal organs (51/59), stratified epithelia (50/58), hyperproliferative keratinocytes (48/56), and simple epithelia (45/52 and 46/54). AE1/AE3 is a broad‐spectrum anti pan‐keratin antibody cocktail which differentiates epithelial from non‐epithelial tumors.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa; IgG2a kappa
  
  Reactivity
  
  human
  
  Clone
  
  AE1/AE3
  
  Immunogen
  
  Human epidermal keratin
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only