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Overview
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The Ki‐67 protein is a nuclear protein doublet, 345‐395 kDa, playing a pivotal role in maintaining cell proliferation. In diagnostic histopathology and cell biology, the antibody has proven valuable for the demonstration of the Ki‐67 antigen in normal and neoplastic cells, for example in soft‐tissue sarcoma, prostatic adenocarcinoma, and breast carcinoma. The Ki‐67 has been confirmed as a very powerful single prognostic factor for overall survival, with highly proliferative cases showing a much poorer outcome than tumors with low proliferation. In breast cancer, the proliferative index measured by Ki‐67 immunoreactivity has both prognostic and predictive value.
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