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Overview
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Directed against the 58 kD and 52.2 kD keratin proteins (keratins K5 and K8; formerly alsodesignated cytokeratins 5 and 8 in the Moll catalogue of keratins), reacts with all epithelial cell types. Noreaction is observed in nonepithelial tissues. The antibody can be used for the discrimination ofcarcinomas from non-epithelial tumors such as lymphomas, sarcomas and neural tumors. RCK 102 isapplicable on frozen and paraffin-embedded tissue. Formalin fixation may cause antigen denaturationor masking. Therefore, protease digestion is necessary prior to antibody application.Immunogen: lung cancer cell preparation
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