-
-
Overview
-
Detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embeddedtissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbedexogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chainratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a singlelight chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by akappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.
Please contact us at for specific academic pricing.
-
- Properties
- Applications
-
Overview