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Overview
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Recognizes the human junction adhesion molecule (JAM)-A. Together with JAM-C (JAM-2)and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs areimportant for a variety of cellular processes, including tight junction assembly, leukocytetransmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelialand epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all otherJAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesionthrough homophilic interaction. It co-distributes with other tight junction components as ZO-1, 7H6antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration.Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins.
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