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Overview
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Recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) or JAM-1. JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto theimmunoglobulin superfamily found on the surface of human platelets and at intercellular junctions ofendothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM orJAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A playsan important role in tight junctions where it is involved in cell-to-cell adhesion through homophilicinteractions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulinand occludin. Moreover, JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading.In the platelet, JAM-A is a membrane protein involved in 2 distinct processes initiated on the plateletsurface.
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