Name: Anti-INI-1 antibody
Price: 2035.00 USD

Overview
- The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNFchromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Twoisoforms of INI-1 that differ by the variable inclusion of amino acids are potentially produced bydifferential RNA splicing.The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTsrelative to its potential mimics [medulloblastoma, supratentorial primitive neuroectodermal tumors(sPNETs)] is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclearlabeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs arelabeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2a
  
  Reactivity
  
  human
  
  Clone
  
  MRQ-27
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  1 ml supernatant in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
  
  Storage
  
  Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  * For research use only

Applications

Application	Dilutions
IHC	1:100 – 1:500

$851

$1,293

$850

$331