Name: Anti-Human Smoothelin antibody
Price: 2448.00 USD

Overview
- Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found indifferentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblastsand myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.1, 2 Todistinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucialfor accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observedin muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative orweakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task ofstaging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladdertumors.3-8 Differentiating between smooth muscle tumors and other mesenchymal neoplasms of theGI tract can be challenging in small biopsies.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  R4A
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  1 ml supernatant in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
  
  Storage
  
  Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Smoothelin (Gene ID:6525; UniProt:P53814)
  
  * For research use only