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Overview
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Mucins are high molecular weight glycoproteins which constitute the major component of the mucuslayer that protects the gastric epithelium from chemical and mechanical injury. In humans, at least 14mucin genes have been identified that code for the mucin proteins. Mucin genes are expressed in aregulated cell-and tissue-specific manner. The stomach provides a good example of such differentialexpression of mucin genes. MUC1 is detected in mucous cells of the surface epithelium and neckregion of the gastric antrum, as well as in pyloric glands and oxyntic glands of the body region. Theheterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma.
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