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Overview
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Calponin is a 34 kD polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved insmooth muscle contraction mechanism and is restricted exclusively to smooth muscle tissue. Anti-calponin has been found to be useful in staining myoepithelium and is, therefore, useful fordifferentiating benign sclerosing adenosis of the breast from infiltrating ductal carcinoma. Calponinpositivity has also been noted in malignant myoepithelioma and pleomorphic adenoma3 of salivarygland origin, as well as angiomatoid malignant fibrous histiocytoma.
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Overview