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Overview
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Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cellgrowth and differentiation. GPC3 expression has been observed in the majority of hepatocellularcarcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful markerfor HCC. Additionally, this marker is expressed in many yolk sac tumors.
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