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Overview
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Hemoglobin alpha chain belongs to the globin family and is involved in oxygen transport from the lungto the various peripheral tissues. Hemoglobin A is comprised of two alpha chains and two beta chains.Immunohistochemical localization of hemoglobin is excellent as an erythroid marker for the detectionof immature, dysplastic, and megaloblastic erythroid cells in myeloproliferative disorders, such aserythroleukemia. In contrast, myeloid cells, lymphoid cells, plasma cells, histiocytes, andmegakaryocytes do not stain with anti-hemoglobin A.
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