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Overview
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HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA iscapable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenicactivity. HHV8 is associated with three different diseases observed in AIDS patients; Kaposi's sarcoma, primaryeffusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. HHV8 is the likely etiological agent of Kaposi's sarcoma
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