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Overview
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Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on themembrane of cells in most epithelial tissues. Immunoreactivity with the antibody to Ep-CAM has beenseen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression. Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes. Inconjunction with other markers, Ep-CAM can be used as an aid in determining neoplasms of epithelialorigin, such as distinguishing between lung adenocarcinoma and mesothelioma.
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Overview