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Overview
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It recognizes a protein of 83kDa, which is identified as Factor XIIIa. It has been identified in platelets, megakaryocytes, and fibroblast‐like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophagesand dermal dendritic cells. Anti‐factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases are positive), dermatofibrosarcoma protuberans (‐/+) and desmoplastic malignant melanoma (‐). Anti‐factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma
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