Anti-DKC1 antibody

Catalog Number:

A001033763STJ

Mfr. No.:

STJ23384

Price:

$297

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Overview
- This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  H/Aca Ribonucleoprotein Complex Subunit Dkc1; Cbf5 Homolog; Dyskerin; Nopp140-Associated Protein Of 57 Kda; Nucleolar Protein Nap57; Nucleolar Protein Family A Member 4; Snornp Protein Dkc1 (Gene ID:1736; UniProt:O60832)
  
  * For research use only