Name: Anti-Survivin antibody
Price: 224.00 USD

Overview
- Survivin is a protein encoded by the BIRC5 gene which is approximately 16, 3 kDa. Survivin is localised to the cytoplasm and nucleus. It is involved in apoptosis modulation and signalling, IL-23 signalling pathway and mitotic cell cycle. This protein falls under the inhibitor of apoptosis gene family. It is a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is expressed in the fetal kidney and liver, and to lesser extent, in the lung and brain. Mutations in the BIRC5 gene may result in ovarian epithelial cancer and cervical carcinosarcoma. STJ97436 was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous survivin protein.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; rat
  
  Clone
  
  Mix
  
  Immunogen
  
  Recombinant Protein
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Baculoviral Iap Repeat-Containing Protein 5; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin (Gene ID:332; UniProt:O15392)
  
  * For research use only

Applications

Application

WB; IHC (paraffin)

Application	Dilutions
WB	1:1000-2000
IHC	1:200-500

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Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Western blot analysis of 1) Hela, 2) 293, 3) PC12 using Survivin monoclonal antibody.

Anti-Survivin antibody

Anti-Survivin antibody