Name: Anti-CHOP antibody
Price: 224.00 USD

Overview
- CHOP is a protein encoded by the DDIT3 gene which is approximately 19, 1 kDa. CHOP is localised to the cytoplasm and nucleus. It is involved in the unfolded protein response, the MAPK signalling pathway and apoptosis modulation and signalling. This protein falls under the CCAAT/enhancer-binding protein family of transcription factors. It functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP and preventing their DNA binding activity. It is activated by endoplasmic reticulum stress and promotes apoptosis. CHOP is expressed in the muscle, nervous system, eye, liver and heart. Mutations in the DDIT3 gene may result in myxoid liposarcoma. STJ97774 was developed from clone 2B1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of DDIT3
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; rat; mouse
  
  Clone
  
  2B1
  
  Immunogen
  
  synthetic peptide derived from CHOP
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Dna Damage-Inducible Transcript 3 Protein; Ddit-3; C/Ebp Zeta; C/Ebp-Homologous Protein; Chop; C/Ebp-Homologous Protein 10; Chop-10; Ccaat/Enhancer-Binding Protein Homologous Protein; Growth Arrest And Dna Damage-Inducible Protein Gadd153 (Gene ID:1649; UniProt:P35638)
  
  * For research use only