Name: Anti-phospho-MLKL (S358) antibody
Price: 224.00 USD

Overview
- MLKL is a protein encoded by the MLKL gene which is approximately 54, 4 kDa. MLKL is localised to the cell membrane and cytoplasm. It is involved in the dimerization of procaspase-8, the TNF signalling pathway, apoptosis and autophagy. This protein falls under the protein kinase superfamily. It plays a critical role in tumour necrosis factor-induced necroptosis which is a programmed cell death process. It does this via interaction with the receptor-interacting protein 3 which is a key signalling molecule in necroptosis pathway. MLKL is expressed in the heart, intestine and lung. STJ97776 was developed from clone 6F8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen MLKL. This primary antibody specifically binds to endogenous MLKL protein which only binds about S358 when S358 is phosphorylated.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  6F8
  
  Immunogen
  
  synthetic peptide derived from phospho-MLKL (S358)
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Mixed Lineage Kinase Domain-Like Protein; Hmlkl (Gene ID:197259; UniProt:Q8NB16)
  
  * For research use only