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Overview
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Reacts with CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain +45 kDa non-glykosylated light chain). CD98 is expressed on T lymphocytes (upon activation) andactivated NK cells; it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets.CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of theheterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, isresponsible for cell surface expression and basolateral localization of this transporter complex inpolarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand.Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation.Immunogen: RAJI human Burkitt's lymphoma cell line
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