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Overview
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Reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressedas a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 (beta1 integrinsubunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediatecell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components.This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis.Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumorcells during selection in presence of antitumor drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation.Immunogen: Raji Burkitt's lymphoma cell line
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