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Overview
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
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- Properties
- Applications
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Overview
Immunofluorescence analysis of mouse thymus using CD27 antibody (STJ22984) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of rat thymus using CD27 antibody (STJ22984) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Jurkat cells using CD27 antibody (STJ22984) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded mouse spleen using CD27 antibody (STJ22984) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat spleen using CD27 antibody (STJ22984) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using CD27 antibody (STJ22984) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-CD27 antibody
Anti-CD27 antibody
Catalog Number:
A001033517STJ
Mfr. No.:
STJ22984
Price:
$297
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