Name: Anti-CD33 antibody
Price: 817.00 USD

Overview
- Recognizes the human CD33 cell surface glycoprotein. CD33 is a transmembrane protein ofthe sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptortyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosinephosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells ofmyelomonocytic lineage, binds sialic acid residues in N-and O-glycans on cell surfaces, and is atherapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte andmacrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is alsoexpressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishingmyelogenous leukemia cells from lymphoid or erythroid leukemias.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa
  
  Reactivity
  
  human
  
  Clone
  
  WM53
  
  Immunogen
  
  Human AML cells
  
  Conjugate
  
  FITC
  
  Formulation
  
  100 µg purified antibody conjugated to FITC, in stabilizing Phosphate buffered saline solution, containing 0.1% gelatin, 0.2% BSA and15 mM sodium azide.
  
  Storage
  
  Store antibody at 2-8°C until expiry. Avoid prolonged exposure to light.
  
  Concentration
  
  +/-0.1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Myeloid Cell Surface Antigen Cd33; Sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; Gp67; Cd Antigen Cd33 (Gene ID:945; UniProt:P20138)
  
  * For research use only