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Overview
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CD13 is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on various celltypes. CD13 is a metalloprotease that preferentially catalyzes removal of neutral amino acids fromsmall peptides, thus activating or inactivating bioactive peptides. CD13 also has a role in extracellularmatrix degradation, antigen processing and signal transduction, is important in inflammatoryresponses, regulates intercellular contact, cell motility and vascularization. CD13 is expressed bygranulocytes, monocytes, myeloid leukemia cells, and is involved in protection of leukemic cellsagainst apoptosis and its expression associated with poor prognosis of carcinomas. CD13 functions asan aminopeptidase enzyme and is also alpha receptor for coronavirus.Immunogen: Human CD13
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Overview