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Overview
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The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Overview
Immunohistochemistry of paraffin-embedded human colon carcinoma using APBB1 antibody (STJ26186) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of U2OS cells using APBB1 antibody (STJ26186). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using APBB1 antibody (STJ26186) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-APBB1 antibody
Anti-APBB1 antibody
Catalog Number:
A001035373STJ
Mfr. No.:
STJ26186
Price:
$297
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