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Overview
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This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
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- Properties
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Overview
Immunofluorescence analysis of HeLa cells using TAPBP antibody (STJ115320). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat liver using TAPBP antibody (STJ115320) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using TAPBP antibody (STJ115320) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using TAPBP antibody (STJ115320) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-TAPBP antibody
Anti-TAPBP antibody
Catalog Number:
A001022217STJ
Mfr. No.:
STJ115320
Price:
$297
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