Name: Anti-GPC3 antibody
Price: 331.00 USD

Overview
- Glypican‐3 (GPC3) is a member of the glypican family of glycosyl phosphatidylinositol‐anchored cell‐surface heparan sulfate proteoglycans. The 1G12 monoclonal antibody has been used to assess GPC3 expression in malignant and nonmalignant liver tissue samples by immunohistochemistry in formalin‐faxed and paraffin‐embedded tissue. Studies have shown that GPC3 is expressed at the protein level in most hepatocellular carcinomas, but it is undetectable in normal liver and benign hepatic lesions, including dysplastic and cirrhotic nodules. In addition, GPC3 is significantly elevated the serum of a large proportion of patients with hepatocellular carcinoma. Based on these results, it has been proposed that GPC3 could be a useful marker to differentiate between benign and malignant liver diseases.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa
  
  Reactivity
  
  human
  
  Clone
  
  1G12
  
  Immunogen
  
  A fragment containing the last 70 amino acids of the core glypican‐3 protein
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Culture supernatant diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only