Name: Anti-AMACR+P63+HMW CK antibody
Price: 437.00 USD

Overview
- DOG1 gene, a gastrointestinal stromal tumor (GIST) specific gene, encoding for the hypothetical protein FLJ10261, which was named “Discovered on GIST 1” (DOG1). DOG1 protein is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRa mutation status. DOG1‐1 monoclonal antibody yielded positive staining in 95% GIST. For special GISTs, DOG1 immunoreactivity was detected in 79%, while only 9% stained for CD117; in 36% KIT‐negative GISTs; in 100% NF1‐associated GISTs; and in 82% pediatric GISTs. In addition, DOG1.1 immunoreactivity was seen in fewer cases of carcinoma, melanoma, and seminoma as compared with KIT mutation. Therefore, DOG1.1 is a sensitive and specific immunohistochemical marker for GIST, comparable with KIT, with the additional benefit of detecting KIT‐negative GISTs. DOG1.1 is also a sensitive marker for unusual GIST subgroups lacking KIT or PDGFRA mutations. In tumors that are negative for both KIT and DOG1.1, mutational screening may be required to confirm the diagnosis of GIST.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit; mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG; IgG1; IgG2a
  
  Reactivity
  
  human
  
  Clone
  
  13H4 + ZM70 +34βE12
  
  Immunogen
  
  Human AMACR (P504S), p63, and CKHMW (34βE12) polypeptides
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Alpha-Methylacyl-Coa Racemase; 2-Methylacyl-Coa Racemase (Gene ID:23600; UniProt:Q9UHK6)
  
  * For research use only