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Overview
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p16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor‐derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.
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Overview
Formalin-fixed, paraffin-embedded high grade cervical intraepithelial neoplasia (CINIII) stained with anti-p16 antibody. Note the nuclear and cytoplasmic staining of dysplastic cells (lower right), and the normal squamoujs mucosa is negative (upper left) Formalin-fixed, paraffin-embedded high grade cervical intraepithelial neoplasia (CINIII) stained with anti-p16 antibody. Note the nuclear and cytoplasmic staining of dysplastic cells (lower right), and the normal squamoujs mucosa is negative (upper left)
Anti-P16INK4a antibody
Anti-P16INK4a antibody
Catalog Number:
IGA1029402STJ
Mfr. No.:
STJ180203
Price:
$331
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