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AMG 510

AMG 510

Catalog Number:
FC01366360APE
Mfr. No.:
APE-B8399
Price:
$368
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          AMG-510 is an effective, orally bioavailable, selective KRAS G12C covalent inhibitor. AMG-510 locks KRAS G12C in an inactive GDP constraint. AMG-510 is the first KRAS G12C inhibitor to be clinically developed, which can cause KRAS G12C tumor regression.

      • Properties
        • Alternative Name
          4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
          Molecular Formula
          C30H30F2N6O3
          Molecular Weight
          560.59
          Purity
          98.00%
          Solubility
          insoluble in H2O; ≥27.4 mg/mL in EtOH; ≥42.3 mg/mL in DMSO
          Storage
          Store at -20°C
          SMILES
          O=C(N1CCN([[email protected]@H](C)C1)C2=NC(N(C3=C2C=C(C(C4=C(O)C=CC=C4F)=N3)F)C5=C(C=CN=C5C(C)C)C)=O)C=C

          * For Research Use Only

    Documents

    COA (Certificate Of Analysis)

    MSDS (Material Safety Data Sheet)

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