Name: BAY1895344
Price: 339.00 USD

- Overview
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    Background
    
    BAY-1895344 is a potent and selective ATM inhibitor with IC50 of 7 nM. BAY 1895344 shows strong anti-tumor efficacy in monotherapy and forms a strong combined potential with the targeted alpha therapy Radium-223 dichloride.BAY 1895344 has no activity in hERG patch-clamp assay. In the tumor model of DNA damage defects, BAY 1895344 single drug administration or combined treatment with other DNA damage-inducing therapies have good efficacy.
- Properties
  - Alternative Name
    
    (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride
    
    Molecular Formula
    
    C20H22ClN7O
    
    Molecular Weight
    
    411.89
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥49 mg/mL in EtOH; ≥51.8 mg/mL in H2O; ≥53.4 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C[[email protected]](COCC1)N1C2=CC(C3=CC=NN3C)=C4C(C(C5=CC=NN5)=NC=C4)=N2.Cl
    
    * For Research Use Only