6xHis-Ube2H (UbcH2)

- Overview
  - Ube2H is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2H is the human homolog to its yeast counterpart, Ubc8. Ube2H ubiquitinates histone H2A in vitro without the assistance of any E3 ligase. This E2 could also play a role in the development autism disorder because of its location on the 7q32 chromosomal region.
    
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- Properties
  - Protein Name
    
    UBC8; UBCH; UBCH2; E2-20K
    
    Source
    
    Bacterial recombinant
    
    Formulation
    
    20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
    
    Storage
    
    Store at -80°C; avoid multiple freeze-thaw cycles
    
    Concentration
    
    See tube label
    
    Molecular Weight
    
    20.7 kDa
    
    Sequence
    
    NCBI RefSeq: NM_003344
    
    * Research Use Only