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Overview
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Lipopeptoid with antifungal activity.
γ-2 is a trimeric lipopeptoid with antifungal activity against Cryptococcus neoformans and minimal mammalian cell toxicity. γ-2 is an optimized derivation of AEC5 and has improved potency towards C. neoformans and decreased toxicity towards NIH/3T3 mouse fibroblasts, with a selectivity ratio improved from 8 for AEC5 to 21 for γ-2.
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Overview