Name: NP-12
Price: 301.00 USD

- Overview
  - PD-1 – PD-L1 interaction blocker.
    NP-12 is a branched peptide designed from analysis of the strands and loops of programmed cell death protein 1 (PD-1) at the interface of the PD-1/ programmed cell death ligand 1 (PD-L1) interaction. NP-12 binds to PD-L1 and is a functional equipotent antagonist of both PD-L1 and PD-L2 signalling. In preclinical models of melanoma, colon cancer, and kidney cancers, NP-12 showed significant efficacy in inhibiting primary tumour growth and metastasis. NP-12 shows antitumour activity in pre-established tumour models either as a single agent or when in combination with other immunologic cell death agents.
    
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    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Protein-Protein Interaction Modulators
    
    Alternative Name
    
    AUNP 12, AUR 012, PD-1 "derived peptide"
    
    Molecular Formula
    
    C142H226N40O48
    
    Molecular Weight
    
    3261.55
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2,SNTSESF-K(SNTSESF)-FRVTQLAPKAQIKE-NH2
    Modification: C terminal amide, amide bridge between Lys-8 and Phe-7 in branch chain
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

NP-12

NP-12

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