KSL 128114

KSL 128114

Catalog Number:
P004516980LIF
Mfr. No.:
PEPTIDE-PP-030
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  • Size:
    1mg
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      • Overview

        • Binds the PDZ1 domain of syntenin.
          KSL 128114 is a potent, and metabolically stable peptide inhibitor of syntenin, which binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and shows an inhibitory effect on primary glioblastoma cell viability. KSL 128114 significantly extends survival time in a patient derived glioblastoma xenograft mouse model.

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      • Properties
        • Categories
          Protein-Protein Interaction Modulators
          Molecular Formula
          C94H163N39O20
          Molecular Weight
          2201.6
          Appearance
          Freeze dried solid
          Purity
          >95%
          Solubility
          Soluble in water
          Other Properties
          Sequence: Ac-(D)Arg-Arg-(D)Arg-Gly-(D)Arg-Lys-(D)Lys-Arg-(D)Arg-Ser-His-Trp-Tle-Chg-Asp-Ile-OH,Ac-rRrGrKkRrSHW(Tle)(Chg)DI
          Modification: N terminal is acetylated, arginines 1, 3, 5 and 9 and lysine 7 are D amino acids, Tle is tert butyl glycine and Chg is cyclohexylglycine
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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