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JIB-04

JIB-04

Catalog Number:

I001528192REA

Mfr. No.:

EI-DEM-009

Price:

$280

Size:

5 mg

Quantity:

Add to Cart:

- Overview
  - (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
    
    JIB-04 is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.
    
    Please contact us at for specific academic pricing.
- Properties
  - Molecular Formula
    
    C17H13ClN4
    
    Molecular Weight
    
    MW=308.8
    
    Appearance
    
    Yellow powder
    
    Solubility
    
    Solubilization: May be dissolved in DMSO (30 mg/ml)
    
    Storage
    
    Store desiccated as supplied at -20°Ctemperature for up to 2 years. Store solutions at -20°C for up to two months.
    
    * For Research Use Only.
- Applications
  - Application
    
    Epigenetic Inhibitors

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