Name: WWL 70
Price: 241.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    WWL 70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) with IC50 value of 70 nM [1].WWL 70 is an O-aryl group-modified derivative of carbamate 18 which is a lead inhibitor of ABHD6 screened out by a functional proteomic strategy. WWL 70 is about 5-fold more potent than carbamate 18. The improved potency makes no difference in selectivity of WWL 70 and carbamate 18 as measured by competitive ABPP with brain membrane proteome. WWL 70 was selective against ABHD6 over other 27 SH activities except for ABHD10 which showed a significant reduction in activity in WWL 70-treated proteomes. However, WWL 70 had no effect on recombinant ABHD10 at concentration of 100 μM, suggesting that ABHD10 was not a real target [1].
    
    [1] Li W, Blankman J L, Cravatt B F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. Journal of the American Chemical Society, 2007, 129(31): 9594-9595.
- Properties
  - Alternative Name
    
    4'-carbamoyl-[1,1'-biphenyl]-4-yl methyl(3-(pyridin-4-yl)benzyl)carbamate
    
    CAS Number
    
    947669-91-2
    
    Molecular Formula
    
    C27H23N3O3
    
    Molecular Weight
    
    437.49
    
    Appearance
    
    A solid
    
    Purity
    
    98.93%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

WWL 70

WWL 70

Background

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