(+)-MK 801 Maleate

- Overview
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    Background
    
    (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties. It is found to be a noncompetitive antagonist of NMDA. MK 801 can penetrate into the central nervous system. In the in vitro assay, MK 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. This binding is reversible even when the concentration of MK 801 is up to 100μM. It is also found that the binding shows a regional specificity. Most of these binding sites are located in the hippocampus. In rat cortical-slice preparations, MK 801 causes a potent blockade of depolarizing responses to NMDA with a high selectivity. This effect is persistent. The blockade can also cause a suppression of the epileptiform activity induced by tetrodotoxin or other neurotoxin [1].
    
    [1] Wong EH, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL . The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.
- Properties
  - Categories
    
    Potent NMDA antagonist
    
    Alternative Name
    
    (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
    
    CAS Number
    
    77086-22-7
    
    Molecular Formula
    
    C20H19NO4
    
    Molecular Weight
    
    337.37
    
    Appearance
    
    A solid
    
    Purity
    
    99.27%
    
    Solubility
    
    ≥16.85 mg/mL in DMSO; ≥28.5 mg/mL in EtOH; ≥5.12 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C[[email protected]]1(N2)C3=C(C=CC=C3)C[[email protected]@H]2C4=C1C=CC=C4.O=C(O)/C=C\C(O)=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

HPLC (Retest)

NMR (Nuclear Magnetic Resonance)

MSDS (Material Safety Data Sheet)

Datasheet

(+)-MK 801 Maleate

Background

Documents

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