Name: WP1066
Price: 223.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    WP1066, an analogue of AG490, is a novel and potent inhibitor of janus kinase 2 (JAK2), which inhibits the phosphorylation of JAK2 and degrades JAK2 protein consequently blocking JAK2’s downstream signal transducer and activator of transcription (transcription-3 and transcription-5) as well as phosphoinositide-3-kinase pathways in a dose- and time-dependent manner. Results of preliminary studies suggest that WP1066 inhibits the growth of xenograft tumors generated from Caki-1 renal carcinoma cells (RCC) suppressing tumor angiogenesis and exhibits antiproliferative activity in AML colony-forming cells from newly diagnosed AML patients as well as in AML cell lines OCIM2 and K562, which potentiates it to treat RCC, acute myeloid leukemia (AML) and other hematologic maglignancies.
- Properties
  - Alternative Name
    
    (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
    
    CAS Number
    
    857064-38-1
    
    Molecular Formula
    
    C17H14BrN3O
    
    Molecular Weight
    
    356.22
    
    Appearance
    
    A solid
    
    Purity
    
    99.84%
    
    Solubility
    
    insoluble in H2O; ≥17.8 mg/mL in DMSO; ≥24.6 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Wang J, Gao WJ, et al. “High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis." Stem Cell Res Ther. 2019 Jul 29;10(1):227. PMID:31358059

WP1066

WP1066

Background

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