Name: CYT387
Price: 220.00 USD

- Overview
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    Background
    
    CYT387, an aminopyrimidine derivative discovered by high-throughput enzyme and cell-based screening along with the optimization using structure-guided medicinal chemistry, is a potent and selective inhibitor of janus kinase 1 (JAK1), janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) with values of 50% inhibition concentration IC50 of 11 nM, 18 nM, 155 nM and 17 nM respectively. Recent studies have revealed that CYT387, at low nanomolar concentrations ranging between 500 and 1500 nM, is able to inhibit JAK2 signaling pathway, suppress proliferation and induce apoptosis in JAK2-dependent hematopoietic cell lines with non-hematopoietic cell lines intact.
- Properties
  - Alternative Name
    
    Cyt-387,MOMELOTINIB,CYT 387,CYT 11387; N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide
    
    CAS Number
    
    1056634-68-4
    
    Molecular Formula
    
    C23H22N6O2
    
    Molecular Weight
    
    414.46
    
    Appearance
    
    A solid
    
    Purity
    
    99.69%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Challa S, Husain K, et al. "Targeting the IκB Kinase Enhancer and Its Feedback Circuit in Pancreatic Cancer." Transl Oncol. 2020;13(2):481–489. PMID:32004866
    2. Cing?z O, Goff SP. "Cyclin-dependent kinase activity is required for type I interferon production." Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2950-E2959. PMID:29507205

CYT387

CYT387

Background

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