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Overview
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Virginiamycin S1 is a cyclic hexadepsipeptide. Together with Virginiamycin M1 as a mixture, it works synergistically against Gram-positive bacteria with bateriostatic properties. Commercial preparations of Virginiamycin is 25% S1 and 75% M1. Virginiamycin S1 differs from Virginiamycin B in that it lacks the dimethylamino moiety of the phenyl ring. Virginiamycin S1 is soluble in ethanol, methanol, DMSO, and DMF.
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Background
Virginiamycin S1 binds to the bacterial 50S ribosomal subunit, preventing aminoacyl-tRNA binding and peptide bond formation, thus inhibiting protein synthesis. The visG gene is required for biosynthesis of Virginiamycin S1.
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