Name: Vincristine sulfate
Price: 228.00 USD

- Overview
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    Background
    
    Vincristine is a naturally occurring alkaloid that potently inhibits the tubulin addition with the inhibition constant Ki value of 0.085 μM and exhibits an anti-proliferative activity against B16 melanoma cells with the half maximal inhibition concentration IC50 value of 0.45 M [1].
    Vincristine is extracted from leaves of the periwinkle plant Catharanthus roseus (L.) G. Don of the family Apocynaceae and has an asymmetric structure consisting of two dimers, a dihydroindole nucleus (vindoline) and an indole nucleus (catharanthine), that are linked by a carbon-carbon bond [2].
    Vincristine has been found to be active against a wild range of malignancies, including acute lymphoblastic leukemia (ALL), acute non-lymphoblastic leukemia (ANLL), non-Hodgkin lymphoma (NHL), Hodgkin’s disease and brain tumors [2].
    
    [1] Jordan MA, Himes RH, Wilson L. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 Jun;45(6):2741-7.
    [2] Gidding CE1, Kellie SJ, Kamps WA, de Graaf SS. Vincristine revisited. Crit Rev Oncol Hematol. 1999 Feb;29(3):267-87.
- Properties
  - CAS Number
    
    2068-78-2
    
    Molecular Formula
    
    C46H58N4O14S
    
    Molecular Weight
    
    923.04
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥46.15 mg/mL in DMSO; ≥57 mg/mL in EtOH; ≥58.5 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]]1(CC)CN(CC2)C[[email protected]@](C1)([H])C[[email protected]](C(OC)=O)(C3=C(OC)C=C(N(C=O)[[email protected]]4([H])[[email protected]@]56C7[[email protected]](C=CCN7CC6)(CC)C(OC(C)=O)[[email protected]@]4(C(OC)=O)O)C5=C3)C8=C2C9=CC=CC=C9N8.OS(O)(=O)=O
    
    * For Research Use Only
- Applications
  - Application Description
    
    Microtubule disrupter, antitumor agent